RiteMED Glibenclamide Special Precautions

Patients who are taking glibenclamide should take appropriate caution when driving, crossing the street, or operating machinery, in case hypoglycemia occurs. Intensive education and supervision is beneficial when prescribing glibenclamide and other oral hypoglycemic drugs to patients who may be fasting due to religious reasons (e.g. Ramadan).
Caution must be taken when giving glibenclamide to patients who are debilitated, malnourished and those with adrenal or pituitary insufficiency.
Use in patients with renal and hepatic impairment: Glibenclamide should be used with caution when given to patients with renal insufficiency and hepatic impairment. Risk of hypoglycemia is increased in the presence of severe hepatic impairment.
Use in patients with cardiovascular disease: Patients with cardiovascular disease must use glibenclamide with caution as this may cause hypoglycemia.
Use in Pregnancy: See Use in Pregnancy & Lactation section for further information.
Use in Lactation: See Use in Pregnancy & Lactation section for further information.
Use in the Elderly: Glibenclamide should be used with caution in elderly patients whom the incidence of hypoglycemia is at high risk.