RiteMED Glibenclamide Adverse Reactions

Among the adverse effects reported with the use of glibenclamide are headache, sleepiness, dizziness, nausea, vomiting, heart-burn, diarrhea, constipation, abdominal pain, pruritus, rashes and photosensitivity. Also associated with the use of glibenclamide are cholestatic jaundice, eosinophilia, transient leucopenia, thrombocytopenia, aplastic anemia, agranulocytosis, haemolytic anemia, erythema multiforme, and exfoliative dermatitis.
The occurence of hypoglycemia in patients taking glibenclamide is sometimes severe and prolonged. Lack of familiarity with the potent effects of the drug may lead to fatal outcomes. Hypoglycemic coma was also reported with glibenclamide use.
Increased appetite and weight gain may occur with the use of glibenclamide.
Glibenclamide is said to have mild diuretic action and may enhance water clearance.
In one study, a patient with diabetes mellitus type II developed myopia two days after initial treatment with glibenclamide. The visual difficulty, though, was resolved upon cessation of the use of the drug.