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Glibenclamide is contraindicated to patients with insulin dependent diabetes mellitus or DM type I, to pregnant and lactating patients and to patients with significant hepatic and renal insufficiency.
In non-insulin dependent diabetes mellitus (NIDDM), glibenclamide is not recommended to be given to patients with hepatic or renal failure, ketoacidosis and those under stress, with severe infection, trauma or other severe conditions where the drug would unlikely control hyperglycemia. It is not safe to give glibenclamide to patients with porphyria.
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