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Glibenclamide is initiated at 2.5 to 5 mg and is best given daily immediately before breakfast.
When necessary, the dose of the drug is adjusted at intervals with 2.5 mg increments, not to exceed 20 mg per day, although increasing it to 15 mg is unlikely to cause further benefit.
Doses more than 10 mg per day may be given in divided doses. The second dose is best given immediately before dinner.
Oral hypoglycemic drugs are given as adjuncts to diet modification in diabetic patients.
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