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There is some clinical and laboratory evidence of partial-cross allergenicity between other carbapenems and beta-lactam antibiotics, penicillins and cephalosporins. As with all beta-lactam antibiotics, rare hypersensitivity reactions have been reported. Before initiating therapy with Meropenem Trihydrate (MEROP) Injection careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics.
Meropenem Trihydrate (MEROP) Injection should be used with caution in patients with such a history. If an allergic reaction for Meropenem Trihydrate (MEROP) Injection occurs, the drug should be discontinued and appropriate measures taken.
Use in Children: Efficacy and tolerability in infants under 3 months old have not been established; therefore, Meropenem Trihydrate (MEROP) Injection is not recommended for use below this age. There is no experience in children with altered hepatic or renal function.
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