Probenecid competes with Meropenem Trihydrate (MEROP) Injection for active tubular secretion and thus inhibits the renal excretion, with the effect of increasing the elimination half-life and plasma concentration of Meropenem Trihydrate (MEROP) Injection. As the potency and duration of action of Meropenem Trihydrate (MEROP) Injection dosed without Probenecid are adequate, the co-administration of Probenecid with Meropenem Trihydrate (MEROP) Injection is not recommended.
Meropenem Trihydrate (MEROP) Injection has been administered concomitantly with other medications without adverse pharmacological interactions. However, no other specific data regarding potential drug interactions is available (apart from probenecid as previously mentioned).
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