Merop Dosage/Direction for Use

Adults: The dosage and duration of therapy shall be established depending on type and severity of infection and the condition of the patient.
The recommended daily dosage is as follows: See Table 1.

Click on icon to see table/diagram/image

Dosage Schedule for Adults with Impaired Renal Function: Dosage should be reduced in patients with creatinine clearance less than 51 mL/min, as scheduled as follows. (See Table 2.)

Click on icon to see table/diagram/image

Meropenem Trihydrate (MEROP) Injection is cleared by hemodialysis; if continued treatment with Meropenem Trihydrate (MEROP) Injection is necessary, it is recommended that the unit dose (based on the type and severity of infection) be administered at the completion of the hemodialysis procedure to restore therapeutically effective plasma concentrations.
There is no experience with the use of Meropenem Trihydrate (MEROP) Injection in patients under peritoneal dialysis.
Dosage in Adults with Hepatic Insufficiency: No dosage adjustment is necessary in patients with hepatic insufficiency.
Elderly Patients: No dosage adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 mL/min.
Children: For children over 3 months and up to 12 years of age the recommended dose is 10 to 20 mg/kg every 8 hours depending on type and severity of infection, susceptibility of the pathogen and the condition of the patient. In children over 50 kg weight, adult dosage should be used.
For children aged 4 to 18 years with cystic fibrosis, doses ranging from 25 to 40 mg/kg every 8 hours. There is no experience in children with renal impairment.
Preparation of Solution: For Intravenous Bolus Administration: Meropenem Trihydrate (MEROP) Injection (500 mg and 1 gram) is compatible with the following infusion fluids: Sterile Water for Injection.
Sodium Chloride Injection (0.9% w/v).
Dextrose Injection (5% w/v).
Dextrose Injection (10% w/v).
Dextrose and Sodium Chloride Injection (5% w/v & 0.9% w/v).
Ringer's Lactate Injection.
Use freshly prepared solutions of Meropenem Trihydrate (MEROP) Injection for IV Injection and Infusion.
As shown as follows, the following diluents maintain satisfactory potency at room temperature (15°C to 25°C) or under refrigerated temperature (4°C). (See Table 3.)

Click on icon to see table/diagram/image

For Infusion: Infusion vials (500 mg and 1 g) may be directly constituted with a compatible infusion fluid. Alternatively, an injection vial may be constituted, then the resulting solution added to an I.V. container and further diluted with an appropriate infusion fluid.
Method of Administration: Meropenem Trihydrate (MEROP) Injection to be used for bolus intravenous injection should be constituted with sterile water for injections (10 mL per 500 mg meropenem). This provides an approximate concentration of 50 mg/mL. Constituted solutions are clear, and colorless or pale yellow.
Meropenem Trihydrate (MEROP) Injection for intravenous infusion may be constituted with compatible infusion fluids (50 to 200 mL).
When constituted as instructed (see Preparation of Solution as previously mentioned), each 1 gram Meropenem Trihydrate (MEROP) Injection vial will deliver 1 g of meropenem and 90.2 mg of sodium as sodium carbonate (3.92 mEq).