Kefsyn/Kefsyn 750 Warnings

Kefsyn 750: Before instituting therapy with Cefuroxime, careful history of hypersensitivity reactions to Cefuroxime, cephalosporins, penicillins or other drugs should be obtained. Therefore, caution should be exercised while treating such patients, as cross sensitivity among beta-lactam antibiotics has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy.
If an allergic reaction to Cefuroxime occurs, discontinue the drug. Serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including Cefuroxime, and may range from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients with diarrhea subsequent to the administration of antibacterial agents. Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia, such as, Clostridium difficile which is a primary cause of "antibiotic-associated colitis". In case of the occurrence of pseudomembranous colitis, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to discontinuation of the drug alone. In moderate to severe cases consideration should be given to management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug effective against Clostridium difficile.