Kefsyn/Kefsyn 750 Drug Interactions

Kefsyn FC tab: Probenecid reduces the renal clearance of Cefuroxime.
Kefsyn granules for oral susp: Drugs that reduce gastric acidity may result in lower bioavailability of Cefuroxime axetil (KEFSYN) compared with that of the fasting state and tend to cancel the effect of enhanced absorption after meal. In common with other antibiotics, Cefuroxime axetil (KEFSYN) may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. As a false negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase methods are used to determine blood/plasma glucose levels in patients receiving cefuroxime axetil. This antibiotic does not interfere in the alkaline picrate assay for creatinine.
Kefsyn 750: Cephalosporin antibiotics at high dosage should be given with caution to patients receiving concurrent treatment with potent diuretics, like furosemide and aminoglycosides, as these combinations are suspected of adversely affecting renal function, though this is not likely to be a problem at the recommended dose levels.