Kefsyn/Kefsyn 750

Kefsyn FC tab/Kefsyn 750 For susceptible infections including bone & joint infections, bronchitis (& other lower resp tract infections), gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft tissue infections), & UTI. Surgical infection prophylaxis. Kefsyn granules for oral susp Upper & lower resp tract, GUT, skin & soft tissue infections & gonorrhea.

Kefsyn FC tab UTI 125 mg bid. Resp tract infections 250-500 mg bid. Adult Pneumonia or acute exacerbations of chronic bronchitis 750 mg-1.5 g bid via IV route followed by 500 mg bid orally in each case. Lyme disease 500 mg bid for 20 days. Uncomplicated gonorrhea 1 g as single dose, may be given w/ probenecid 1 g. Childn >2 yr Otitis media 250 mg bid or 15 mg/kg bid. Max: 500 mg daily. Childn >3 mth 125 mg bid or 10 mg/kg bid. Max: 250 mg daily. Kefsyn granules for oral susp Adult Most infection 250 mg bid. UTI 125 mg bid. Mild to moderate lower resp tract infection eg, bronchitis 250 mg bid. More severe lower resp tract infection or if pneumonia is suspected 500 mg bid. Pyelonephritis 250 mg bid. Uncomplicated gonorrhoea 1 g single dose. Childn ≥2 yr Otitis media or more severe infection 15 mg/kg bid. Max: 500 mg daily. Childn ≥3 mth 10 mg/kg bid. Max: 250 mg daily. Kefsyn 750 IV/IM Adult 750 mg tid, may be increased to 1.5 g tid in severe infections. The frequency of administration can be increased to 6-hrly if necessary, giving total doses of 3-6 g daily. Infant & childn 30-60 mg/kg/day increased to 100 mg/kg daily if necessary, given as 3-4 divided doses. Impaired renal function CrCl <20 mL/min 750 mg bid, 10 mL/min 750 mg once daily. Patient on hemodialysis 750 mg dose should be given at the end of each dialysis. Continuous peritoneal dialysis 750 mg bid.

Kefsyn FC tab: May be taken with or without food. Kefsyn granules for oral susp: Should be taken with food.

Hypersensitivity to cefuroxime, cephalosporin or any other β-lactam antibacterial agent eg, penicillins, monobactams & carbapenems.

Discontinue use in case of severe hypersensitivity reactions. Patients who have experienced allergic reaction to penicillins or other β-lactam antibiotics; history of non-severe hypersensitivity to other β-lactam agents. Use may result in overgrowth of Candida. Prolonged use may also result in overgrowth of other non-susceptible microorganisms eg, enterococci & Clostridium difficile. Pseudomembranous colitis. Monitor renal & haematological status especially during prolonged & high dose therapy. Patients w/ renal impairment. Pregnancy & lactation. Kefsyn FC tab: Jarisch-Herxheimer reaction following treatment of Lyme disease. Development of +ve Coombs test may interfere w/ cross matching of blood. False -ve result may occur in ferricyanide test. Granules for oral susp: Consider sucrose content when treating DM patients. Contains aspartame; caution in patients w/ phenylketonuria. False -ve result may occur in ferricyanide test. May impair ability to drive or operate machinery. Kefsyn 750 Concurrent use w/ diuretics. Safety & effectiveness have not been established in childn <3 mth.

Kefsyn FC tab: GI disturbances, including diarrhea, nausea, & vomiting. Granules for oral susp: Overgrowth of Candida; eosinophilia; headache, dizziness; GI disturbances, including diarrhea, nausea, abdominal pain; transient increase in hepatic enzyme levels (ALT, AST, lactate dehydrogenase). Kefsyn 750 GI disturbances, including diarrhea, nausea, & vomiting. Transient pain at the site of IM inj; skin rashes (maculopapular & urticaria), drug fever; pseudomembranous colitis; decreased Hb conc &/or eosinophilia, leukopenia & neutropenia; transient rise in SGOT & SGPT, & bilirubin.

Kefsyn FC tab: Reduced renal clearance w/ probenecid. Granules for oral susp: Bioavailability may be reduced w/ drugs that reduce gastric acidity. May affect gut flora leading to lower estrogen reabsorption & reduced efficacy of combined OCs. Kefsyn 750 Concurrent use w/ potent diuretics eg, furosemide & aminoglycosides may adversely affect renal function.

Cephalosporins

J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

Rx