Kefsyn/Kefsyn 750 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Kefsyn Cefuroxime axetil. Kefsyn 750 Cefuroxime Na

Indications/Uses

For susceptible infections including bone & joint infections, bronchitis (& other lower resp tract infections), gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft tissue infections), & UTI. Surgical infection prophylaxis.

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Dosage/Direction for Use

Kefsyn FC tab UTI 125 mg bid. Resp tract infections 250-500 mg bid. Adult Pneumonia or acute exacerbations of chronic bronchitis 750 mg-1.5 g bid via IV route followed by 500 mg bid orally in each case. Lyme disease 500 mg bid for 20 days. Uncomplicated gonorrhea 1 g as single dose, may be given w/ probenecid 1 g. Childn >2 yr Otitis media 250 mg bid or 15 mg/kg bid. Max: 500 mg daily. Childn >3 mth 125 mg bid or 10 mg/kg bid. Max: 250 mg daily. Kefsyn 750 IV/IM Adult 750 mg tid, may be increased to 1.5 g tid in severe infections. The frequency of administration can be increased to 6-hrly if necessary, giving total doses of 3-6 g daily. Infant & childn 30-60 mg/kg/day increased to 100 mg/kg daily if necessary, given as 3-4 divided doses. Impaired renal function CrCl <20 mL/min 750 mg bid, 10 mL/min 750 mg once daily. Patient on hemodialysis 750 mg dose should be given at the end of each dialysis. Continuous peritoneal dialysis 750 mg bid.

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Overdosage

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Administration

Kefsyn FC tab May be taken with or without food.

Contraindications

Hypersensitivity to cefuroxime, cephalosporin or any other β-lactam antibacterial agent eg, penicillins, monobactams & carbapenems.

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Warnings

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Special Precautions

Discontinue use in case of severe hypersensitivity reactions. Patients who have experienced allergic reaction to penicillins or other β-lactam antibiotics; history of non-severe hypersensitivity to other β-lactam agents. Use may result in overgrowth of Candida. Prolonged use may also result in overgrowth of other non-susceptible microorganisms eg, enterococci & Clostridium difficile. Pseudomembranous colitis. Monitor renal & haematological status especially during prolonged & high dose therapy. Patients w/ renal impairment. Pregnancy & lactation. Kefsyn Jarisch-Herxheimer reaction following treatment of Lyme disease. Development of +ve Coombs test may interfere w/ cross matching of blood. False -ve result may occur in ferricyanide test. Kefsyn 750 Concurrent use w/ diuretics. Safety & effectiveness have not been established in childn <3 mth.

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Use In Pregnancy & Lactation

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Adverse Reactions

GI disturbances, including diarrhea, nausea, & vomiting. Kefsyn 750 Transient pain at the site of IM inj; skin rashes (maculopapular & urticaria), drug fever; pseudomembranous colitis; decreased Hb conc &/or eosinophilia, leukopenia & neutropenia; transient rise in SGOT & SGPT, & bilirubin.

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Drug Interactions

Kefsyn Reduced renal clearance w/ probenecid. Kefsyn 750 Concurrent use w/ potent diuretics eg, furosemide & aminoglycosides may adversely affect renal function.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Cephalosporins

ATC Classification

J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Kefsyn FC tab 500 mg

Packing/Price

10's (P63.72/film-coated tab)

Form

Kefsyn 750 powd for inj 750 mg

Packing/Price

1's (P324/box)

Kefsyn/Kefsyn 750

cefuroxime

Manufacturer:

Ambica

Distributor:

GXI