Kefsyn/Kefsyn 750 Dosage/Direction for Use

Kefsyn FC tab: For Uncomplicated Urinary Tract Infections: 125 mg twice daily.
For Respiratory Tract Infections: 250 to 500 mg twice daily.
A dose for children more than 3 months of age: 125 mg twice daily or 10 mg/kg twice daily to a maximum of 250 mg daily.
Children over 2 years of age with otitis media: 250 mg twice daily or 15 mg/kg twice daily to a maximum of 500 mg daily.
Adults with Pneumonia or with Acute Exacerbations of Chronic Bronchitis: 1.5 g twice daily or 750 mg twice daily, respectively, in parenteral route followed by oral Cefuroxime 500 mg twice daily in each case.
For Lyme disease in adults: 500 mg is given twice daily for 20 days.
For Uncomplicated Gonorrhea: A single 1 g oral dose of Cefuroxime can be given. In each case an oral dose of Probenecid 1 g may be given with Cefuroxime. Or as prescribed by the physician.
Kefsyn granules for oral susp: The usual course of therapy is seven days. (Range 5-10 Days.)
For optimal absorption cefuroxime axetil should be taken with food.
Adults: Most infections: 250 mg BID.
Urinary tract infections: 125 mg BID.
Mild to moderate lower respiratory tract infections e.g. bronchitis: 250 mg BID.
More severe lower respiratory tract infections, or if pneumonia is suspected: 500 mg BID.
Pyelonephritis: 250 mg BID.
Uncomplicated gonorrhoea: Single dose 1 g.
Children: When prescription of a fixed dose is preferred, the recommended dose for most infections is 125 mg twice daily. In children aged two years or older with otitis media or where appropriate, with more severe infections the dose is 250 mg twice daily, to a maximum of 500 mg daily. There is no clinical trial data available on the use of Cefuroxime axetil (KEFSYN) in children under the age of 3 months. In infants and children, it may be preferable to adjust dosage according to weight or age. The dose in infants and children 3 months to 12 years is 10 mg/kg twice daily for most infections to a maximum of 250 mg daily. In otitis media or more severe infections the recommended dose is 15 mg/kg twice daily to a maximum of 500 mg daily. The following two tables divided by age group and weight serve as a guideline for simplified administration from measuring spoons (5 mL) for the 125 mg/5 mL or the 250 mg/5 mL suspension.
10 mg/kg dosage for most infections: See Table 1.

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15 mg/kg dosage for otitis media and more serious infections: See Table 2.

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To enhance compliance and improve the dosing accuracy in very young children, a dosing syringe can be used with amber bottle containing 50 mL of suspension. However, dosing in spoonfuls should be considered a more favorable option if the child is able to take the medication from the spoon. If required, the dosing syringe may also be used in older children (see dosing tables as follows). The recommended doses for the pediatric dosing syringe are expressed in mL or mg and according to bodyweight in Tables 3 and 4 as follows. (See Tables 3 and 4.)
10 mg/kg/dose (Pediatric dosing syringe): See Table 3.

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15 mg/kg/dose (Pediatric dosing syringe): See Table 4.

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Cefuroxime is also available as the sodium salt for parenteral administration. This permits parenteral therapy with cefuroxime to be followed by oral therapy in situations where a change from parenteral to oral treatment is clinically indicated.
Kefsyn 750: Cefuroxime may be administered intravenously or intramuscularly.
Adults: The usual dose of Cefuroxime is 750 mg three times daily by I.M. or I.V. Injection, which may be increased to 1.5 g three times daily I.V. in severe infections. The frequency of administration can be increased to six-hourly, if necessary, giving total doses of 3 g to 6 g daily.
Infants and children: 30 to 60 mg/kg/day increased to 100 mg/kg daily, if necessary, given as three or four divided doses. A dose of 60 mg/kg/day will be appropriate for most infections.
Elderly: As prescribed by the physician.
Dosage in impaired renal function: As Cefuroxime is excreted by the kidneys, the dosage of Cefuroxime should be reduced in patients with creatinine clearance below 20 mL/min, 750 mg twice daily is recommended and with 10 mL/min, 750 mg once daily is adequate. For patients on hemodialysis, a further 750 mg dose should be given at the end of each dialysis. In case of continuous peritoneal dialysis, 750 mg twice daily is recommended.