Use in pregnancy: Pregnancy Category C. Teratogenic Effects: Teratogenicity has occurred in animals given high doses of fluconazole. There are no adequate and well-controlled studies in pregnant women. There have been reports of multiple congenital abnormalities in infants whose mothers were being treated for ≥3 months with high-dose (400-800 mg/day) fluconazole therapy for coccidioidomycosis (an unindicated use). The relationship between fluconazole use and these events are unclear. Use fluconazole in pregnancy only if the potential risk justifies the possible risk to the fetus.
Use in lactation: Fluconazole is secreted in human milk at concentrations similar to plasma. Therefore, fluconazole is not recommended in nursing mothers.
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