Funzela Dosage/Direction for Use

Since fluconazole has >90% bioavailability, oral and intravenous dosing are the same. The intravenous route should be considered for patients who cannot tolerate or are unable to take fluconazole orally. See Table 2.

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Recommended Dosing Regimen for Children: Usual recommended dose: 3 to 12 mg/kg body weight once daily. Do not exceed 600 mg once daily in children. See Table 3.

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For children less than 4 weeks, the same fluconazole dose as above should be given. However, the dosage regimen is changed as follows: See Table 4.

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The following dose equivalency scheme should generally provide equivalent exposure in paediatric and adult patients. See Table 5.

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Dosage in Patients with Impaired Renal Function: No dosage adjustment is necessary for patients with renal impairment who are to receive a single dose of fluconazole. For patients who need multiple doses of fluconazole, an initial loading dose of 50 to 400 mg is required followed by a daily dose based on creatinine clearance as shown in Table 6.
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These are suggested dose adjustments based on Fluconazole pharmacokinetics after administration of multiple doses in patients with renal impairment. Further dose adjustment may be needed depending on the patient's clinical condition.
When serum creatinine is the only measure of renal function available, use the following formula to estimate the creatinine clearance.

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