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Death, often following clonic seizures, occurred at 1.5 hours to 3 days after administration of 1 to 2 grams of fluconazole. In one patient with human immunodeficiency virus (HIV) infection, hallucinations and paranoid behaviour were reported after ingestion of 8.2 g of fluconazole.
The patient required hospitalization ad the condition resolved after 48 hours.
If acute overdosage occurs, supportive and symptomatic treatment should be initiated as necessary. The stomach may be emptied by gastric lavage. Fluconazole is also removed by hemodialysis and plasma fluconazole concentration usually decreases to 50% after 3-hours of hemodialysis.
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