Exelfos Dosage/Direction for Use

Adults: In acute, not complicated infections of the low urinary tract (cystitis, non-gonococcal urethritis) caused by germs susceptible to fosfomycin, one sachet of Fosfomycin (Exelfos) (3 grams) in a single daily administration.
In the prophylaxis of urinary infections after surgery or transurethral diagnostic maneuvers, the treatment should be applied usually with two doses of Fosfomycin (Exelfos). The first dose (1 sachet of 3 grams) is administered about 3 hours before surgery, the second dose (1 sachet of 3 grams) is administered 24 hours after the first one.
Elderly patients, other clinical situations: In elderly, bed-ridden patients, recurrent infections or infections by susceptible microorganisms to higher doses of antibiotic (Pseudomonas, Enterobacter, Proteus positive-indole) a second dose of fosfomycin trometamol could be necessary 24 hours after the first one.
Patients with renal insufficiency: For patients with mild to moderate renal insufficiency, dose adjustments are not needed. Fosfomycin (Exelfos) is not to be used in patients with severe renal insufficiency, neither during hemodialysis.
Method of administration: Fosfomycin trometamol is administrated as oral solution.
The contents of each sachet, of fosfomycin should be dissolved in half a glass of water (at least 50 mL) and drink it immediately preferably before the night resting, after voiding the bladder.