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There are no data on the effect of acute or chronic overdose of intranasal fluticasone propionate. Intranasal administration of 2 mg fluticasone propionate twice daily for 7 days to healthy volunteers had no effect on hypothalamic-pituitary-adrenal (HPA) axis functions.
Long-term administration of higher than recommended doses may cause temporary suppression of adrenal function.
In these patients, fluticasone propionate treatment should be continued at a dose sufficient to control symptoms; adrenal function will return to normal within a few days and this can be monitored by measuring the plasma cortisol level.
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