Cycomin Special Precautions

Phytomenadione Injection contains a polyethoxylated castor oil as a non-ionic surfactant. In animal studies, polyethoxylated castor oil can produce severe anaphylactoid reactions associated with histamine release. There is a strong circumstantial evidence that similar reactions occurring in patients may have been caused by polyethoxylated castor oil. Polyethoxylated castor oil, when given to patients over a period of several days, can also produce abnormal lipoprotein electrophoretic patterns, alterations in blood viscosity and erythrocyte aggregation.
In potentially fatal and severe hemorrhage due to overdosage of coumarin anticoagulants, intravenous injection of Phytomenadione Injection must be administered slowly and not more than 40 mg should be given during a period of 24 hours. Phytomenadione therapy should be accompanied by a more immediate effective treatment such as transfusions of whole blood clotting factors. When patients with prosthetic heart valves are given transfusions for the treatment of severe or potentially fatal hemorrhages, fresh frozen plasma should be used.
Large doses of phytomenadione should be avoided if it is intended to continue with anticoagulant therapy.
Vitamin K₁, is not an antidote to heparin.