Cycomin Dosage/Direction for Use

Adults: As an antidote to anticoagulant drugs.
For potentially fatal and severe hemorrhage: Phytomenadione therapy should be accompanied by a more immediate effective treatment such as transfusions of whole blood or blood clotting factors. The anticoagulant should be withdrawn and an intravenous injection of Phytomenadione Injection given slowly in a dose of 10-20 mg. The prothrombin level should be estimated three hours later, and if the response has been inadequate, the dose should be repeated. Not more than 40 mg of phytomenadione should be given intravenously in 24 hours.
Less severe hemorrhage: Phytomenadione Injection is given by IM injection in doses of 10-20 mg. The prothrombin level is estimated 8 to 12 hours later and if the response has been inadequate, the dose should be repeated.
Adults: Other indications: Doses of 10-20 mg as required.
Use in the elderly: Elderly patients tend to be more sensitive to reversal of anticoagulation with phytomenadione; dosage in this group should be at the lower end of the ranges recommended for adults.
Children: If, on the recommendation of a physician, a children's dosage is required, then it is suggested that 5-10 mg be given.
Treatment of newborn infants: Prophylactic; If oral prophylaxis is not possible, 1 mg by intramuscular Injection.
Therapeutic: 1 mg by intramuscular injection, repeated at eight hourly intervals if necessary.
Phytomenadione Injection ampoules are for intramuscular or intravenous injection. Phytomenadione Injection should not be diluted.