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Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. It should be used with caution, therefore, in patients receiving such agents.
Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance the two drugs should not be administered concurrently.
The following drugs are physically incompatible with clindamycin phosphate: Ampicillin sodium, phenytoin sodium, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.
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