Clindal/Clindal Injection Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Clindamycin

Indications/Uses

Clindal Treatment of serious anaerobic infections especially those caused by Bacteroides fragilis. Alternative to penicillin in some severe Staph & Strep infections, including Staph osteomyelitis. Clindal Injection Treatment of liver abscess, gas gangrene, pneumonia, septicemia; biliary tract, Staph bone & joint, various gynecological & skin infections. In combination w/ other drugs for the prophylaxis of surgical infection.

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Dosage/Direction for Use

Clindal cap Adult Serious infections 300 mg 6 hrly. Clindal Injection Adult Serious infections 600 mg-1.2 g/day in 2, 3 or 4 equal doses. More severe infections 1.2-2.7 g/day in 2, 3 or 4 equal doses. Life-threatening cases 4.8 g daily IV. Alternatively, may be administered in the form of a single rapid infusion of the 1st dose followed by continuous IV infusion [to maintain serum clindamycin levels >6 mcg/mL: Rapid infusion rate of 20 mg/min for 30 min, maintenance infusion rate of 1.25 mg/min; serum clindamycin levels >5 mcg/mL: Rapid infusion rate of 15 mg/min for 30 min, maintenance infusion rate of 1 mg/min; serum clindamycin levels >4 mcg/mL: Rapid infusion rate of 10 mg/min for 30 min, maintenance infusion rate of 0.75 mg/min]. Childn >1 mth Serious infections 15-25 mg/kg/day in 3 or 4 equal doses. More severe infections 25-40 mg/kg/day in 3 or 4 equal doses. Treatment of infections caused by β-hemolytic streptococci Continue for at least 10 days to protect against subsequent rheumatic fever or glomerulonephritis.

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Administration

May be taken with or without food: Cap: Swallow whole w/ a full glass of water & in an upright position.

Contraindications

Hypersensitivity to lincomycin or clindamycin.

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Warnings

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Special Precautions

Risk of antibiotic-associated colitis. Patients w/ history of GI disease especially colitis; renal or hepatic impairment. Perform periodic liver & kidney function tests during prolonged therapy (including neonate & infants). Prolonged treatment may result to superinfection. Atopic individuals.

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Use In Pregnancy & Lactation

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Adverse Reactions

Nausea, vomiting, abdominal pain, diarrhea; transient neutropenia, eosinophilia, agranulocytosis, thrombocytopenia; pruritus, vaginitis; maculopapular rash, urticaria, generalized mild to moderate morbilliform-like skin rashes; jaundice & abnormalities in liver function tests.

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Drug Interactions

May enhance action of other neuromuscular blockers. Antagonism w/ erythromycin (in vitro).

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Storage

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Description

View Clindal/Clindal Injection description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Other Antibiotics

ATC Classification

J01FF01 - clindamycin ; Belongs to the class of lincosamides. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Clindal cap 150 mg

Packing/Price

100's

Form

Clindal cap 300 mg

Packing/Price

100's

Form

Clindal Injection soln for inj 150 mg/mL

Packing/Price

2 mL x 10 × 1's;4 mL x 10 × 1's

Clindal/Clindal Injection

clindamycin

Manufacturer:

Union Korea Pharm

Distributor:

One Pharma