Clindamycin HCl may cause diarrhea which can be severe and persistent, nausea, vomiting, abdominal cramps and taste abnormality. Severe pseudomembranous colitis has occurred in some patients and has occasionally been fatal. Colitis and diarrhea have been reported during treatment and after its completion. Some reports suggest that the intestinal effects may be due to superinfection. Hypersensitivity reactions including skin rashes and urticaria may occur and transient leukopenia and eosinophilia, elevations of alkaline phosphatase and serum aminotransferases and jaundice have been reported.
Agranulocytosis, thrombocytopenia and erythema multiforme have been observed.