Byden 500

Each film-coated tablet contains Thiamine Mononitrate (Vitamin B₁) 500 mg, Pyridoxine Hydrochloride (Vitamin B₆) 250 mg, Cyanocobalamin (Vitamin B₁₂) 1 mg. BYDEN 500 is a combination of the 3 essential neurotropic vitamins B₁, B₆ and B₁₂ in high dosage. Vitamin B₁, B₆ and B₁₂ are of special importance for the metabolism in the peripheral and central nervous system. Their effect on the regeneration of nerves has been shown in various investigations using the vitamins individually and in combination. Vitamin B₁, B₆ and B₁₂ (BYDEN 500) is a pink film-coated tablet, oval, biconvex, plain on one side, bisected on the other side.

Pharmacology: Vitamin B₁, B₆ and B₁₂ (BYDEN 500) is a combination of the 3 essential neurotropic vitamins B₁, B₆ and B₁₂ in high dosage. Vitamin B₁, B₆ and B₁₂ are of special importance for the metabolism in the peripheral and central nervous system. Vitamin B₁, B₆ and B₁₂ are indispensable to normal nerve cell metabolism and this combination greatly enhances their therapeutic efficacy as compared to the effect of the respective factors given individually. In the human body, Thiamine mononitrate is converted to Thiamine pyrophosphate (active form), which is coenzyme in the decarboxylation of α-keto acids.
On the other hand, pyridoxal hydrochloride will be transferred to pyridoxal phosphate, co-enzyme reaction in carboxylation and transamination, which are involved in protein and amino acid metabolism. Vitamin B₁₂ is essential in nucleic acid and myelin synthesis, for cell growth and replication and maintaining the integrity of the nervous tissue.

Neurological and other disorders associated with disturbance of metabolic functions influenced by B-complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post-influenza neuropathies.
Treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain and ischialgia.

Taken orally.
Prophylaxis: 1-2 tablets daily.
Therapeutic: 2-4 tablets daily.
Or as prescribed by the physician.

Signs and symptoms: Vitamin B₁ and B₁₂ are known to be generally safe in humans when taken at recommended doses.
Symptoms which may be expected are drowsiness, nausea, hypotension, dizziness, excitatory states, respiratory depression, convulsion and coma.
Long-term administration of large doses of pyridoxine can cause sensory neuropathy or neuronopathy syndromes. Peripheral sensory neuropathy has been reported in individuals receiving pyridoxine dosages of 1-4 g daily.

Hypersensitivity to any other active ingredients or excipients of Vitamin B₁, B₆ and B₁₂ (BYDEN 500).
Use in Children: Not suitable for the treatment of children due to the high content of vitamin B-complex.

Neuropathies are described under long-term intake (6-12 months) of >50 mg mean daily dose of Vitamin B₆. Therefore, under long-term treatment, regular monitoring is recommended.
Vitamin B₁, B₆ and B₁₂ (BYDEN 500) tablet contain lactose and sucrose; therefore, its use is not recommended in patients with intolerance to some sugars (i.e. rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrose-isomaltose insufficiency).

Hypersensitivity reactions to Vitamin B₁ e.g. sweating, tachycardia, skin reactions with itching and urticaria are very rare. Gastrointestinal complaints e.g. nausea, vomiting, diarrhea or abdominal pain may occur.
Administration of Vitamin B₁₂ in doses greater than 10 mcg daily may produce haematological response in patients with folate deficiency.

The effect of Levodopa may be reduced when vitamin B₆ is administered concomitantly.
Pyridoxine-antagonists (e.g. Isoniazid, Cycloserine, Penicillamine, Hydralazine): The efficacy of Vitamin B₆ (Pyridoxine) may be decreased.
Loop Diuretics (e.g. Furosemide): In long-term use, the blood level of thiamine may be reduced.

Store at temperatures not exceeding 30°C. Protect from light. Always keep container tightly closed.

Vitamin B-Complex / with C

A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.

Non-Rx