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The effect of Levodopa may be reduced when vitamin B6 is administered concomitantly.
Pyridoxine-antagonists (e.g. Isoniazid, Cycloserine, Penicillamine, Hydralazine): The efficacy of Vitamin B6 (Pyridoxine) may be decreased.
Loop Diuretics (e.g. Furosemide): In long-term use, the blood level of thiamine may be reduced.
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