Arpimune Overdosage

There is a minimal experience with ciclosporin (Arpimune) overdose. Forced emesis and gastric lavage ca be of value up to two hours after administration of ciclosporin (Arpimune). Transient hepatotoxicity and nephrotoxicity may occur which should resolve following drug withdrawal. Oral doses of ciclosporin (Arpimune) up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia, and in a few patients, moderately severe, reversible impairment of renal function. General supportive measure and symptomatic treatment should be followed in all cases of overdose. Ciclosporin (Arpimune) is dialyzable to any great extent, nor is it cleared well by charcoal hemoperfusion. The oral dosage at which half of experimental animals are estimated to dieis 31 and 39 times and >54 times the human maintenance dose for transplant patients (6 mg/kg: corrections based on body surface area) in mice, rats, and rabbits.