Arpimune Dosage/Direction for Use

Solid Organ Transplantation: Initiated 4-12 hrs prior to transplantation at a dose of 10-15 mg/kg, given in 2 divided doses. This dose is continued as 2 divided doses postoperatively for 1-2 weeks. In patients with stable graft function, the dose is then gradually reduced until a maintenance dose of 2-6 mg/kg/day is reached.
Bone Marrow Transplantation: First dose should be administered on the day before transplantation, preferably as an IV infusion. In patients on oral therapy, the dosage is 12.5 mg/kg/day, given in 2 divided doses for at least 3 months and preferably for 6 months before ciclosporin is withdrawn slowly.
Rheumatoid Arthritis: Initiation of therapy should take place over a period of 12 weeks. For the first 6 weeks, the recommended dose is 2.5 mg/kg/day, given orally in 2 divided doses. The daily dose can be increased gradually to a maximum of 4 mg/kg/day, if the clinical effects are insufficient.
Psoriasis: The recommended initial dose is 2.5 mg/kg orally in 2 divided doses. The daily dose may be gradually increased if there is no improvement after 1 month to a maximum of 5 mg/kg.
Atopic Dermatitis: The recommended daily dose range is 2.5-5 mg/kg orally in 2 divided doses for a maximum of 8 weeks.
Nephrotic Syndrome: An oral dose of 5 mg/kg/day in adults or 6 mg/kg/day in children (taken as 2 divided doses) is recommended for function of remission, except in patients with permitted levels of kidney failure in whom starting dose must not exceed 2.5 mg/kg/day.