Ciclosporin (Arpimune) is contraindicated in patients with hypersensitivity to ciclosporin or to any of the ingredients of the formulation. Rheumatoid arthritis patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive ciclosporin (Arpimune). Psoriasis patients who are treated with ciclosporin (Arpimune)should not receive concomitant PUVA or UVB therapy, methothrexate or other immunosuppressive agents, coal tar or radiation therapy. Psoriasis patients with abnormal renal function, uncontrolled hypertension or malignancies should not receive ciclosporin.