Capsule: Excessive intake of this medicine may cause rash, abdominal pain, vomiting, nausea, decreased appetite, fatigue, weight loss, constipation, dehydration, irritability, confusion, headache, difficulty in sleeping, increased heart rate, weakness, bright yellow urine, numbness, allergic reactions, diarrhea, acute renal failure, dizziness, and agitation.
Syrup: Acute intake of large doses of water-soluble vitamins are readily excreted in the urine. No emergency procedure or antidote is applicable, and any symptoms are rapidly reduced upon withdrawal of the preparation. However, the following adverse reactions have been reported: Thiamine hydrochloride (Vitamin B1) Thiamine doses of 5 mg/day for 4 to 5 weeks has resulted in headache, insomnia, irritability, increased heart rate, and weakness.
Riboflavin phosphate (Vitamin B2): Large doses of riboflavin result in a bright yellow discoloration of the urine that may interfere with certain laboratory tests.
Nicotinamide (Vitamin B3): An intake of 3,000 mg/day of vitamin B3 may cause nausea, vomiting and signs of liver toxicity.
Pyridoxine hydrochloride (Vitamin B6): Reversible sensory neuropathy has been reported with chronic intake of high doses of vitamin B6; the dose at which these occur is controversial.
Cyanocobalamin (Vitamin B12): High doses of cyanocobalamin are generally not associated with toxicity although rare allergic and anaphylactic reactions and mild diarrhea have occurred.
Ascorbic acid (Vitamin C): Chronic excessive use and large IV doses can produce increased levels of the metabolite oxalic acid. Urinary acidification promotes calcium oxalate crystal formation, which can result in nephropathy or acute renal failure.
Buclizine hydrochloride: Antihistamine overdose in general can include dizziness, tachycardia, headache, drowsiness, or agitation. While the current generation of lesser sedating antihistamines do not affect the QT interval at normal doses, there are concerns there may be some effect in overdose.
When the patient has taken more than the recommended dosage: Capsule: Consult the doctor immediately if the patient experiences any of the signs and symptoms of overdose.
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