Appetite Plus Drug Interactions

Capsule: Consult the doctor first if the patient is taking contraceptive pills, neomycin, blood-thinning medications, laxatives, calcium supplements, thiazide diuretics, anticonvulsants, fluorouracil, levodopa, altretamine, aspirin, proton pump inhibitors, H2-receptor antagonists, colchicine, chloramphenicol, iron supplements, iron chelating agents, aluminum antacids, oral citrate, analgesics, orlistat, bile acid sequestrants, alcohol, and central nervous system drugs.
Syrup: Thiamine hydrochloride (Vitamin B₁): Fluorouracil increases thiamin metabolism and block the formation of thiamin pyrophosphate that could further exacerbate preexisting thiamine deficiency in cancer patients.
Riboflavin phosphate (Vitamin B₂): There are no known drug interactions.
Nicotinamide (Vitamin B₃): There are no known drug interactions.
Pyridoxine hydrochloride (Vitamin B₆): Vitamin B₆ reduces the effects of levodopa, but this does not occur if a dopa decarboxylase inhibitor is also given.
High doses of vitamin B₆ can decrease serum concentration of phenytoin and phenobarbital.
Vitamin B₆ can reduce the effectiveness of altretamine (hexamethyl melamine).
Cyanocobalamin (Vitamin B₁₂): Aspirin, proton pump inhibitors, H2-receptor antagonists, neomycin, colchicine can reduce the absorption of vitamin B₁₂ from the gut, but no interaction is likely when B₁₂ is given by injection.
Intake of chloramphenicol may cause a milder, reversible bone marrow depression which can oppose the treatment of anemias with vitamin B₁₂.
Ascorbic acid (Vitamin C): Aspirin may reduce vitamin C intestinal absorption, although the clinical importance of this interaction is uncertain. Vitamin C does not seem to affect aspirin serum levels.
Proton pump inhibitors may affect the bioavailability of dietary vitamin C.
High doses of vitamin C may cause cardiac toxicity in patients with iron overload given deferoxamine. Ascorbic acid may increase the absorption of iron in iron-deficiency states. Other iron chelating agents are expected to interact similarly.
Concomitant intake of aluminum antacids and oral citrate among patients with renal failure may predispose to potentially fatal encephalopathy due to markedly increased blood aluminum levels. Evidence suggest that a similar interaction may occur with ascorbic acid.
Taking ascorbic acid with paracetamol can prolong the presence of paracetamol in the blood.
Ascorbic acid has been reported to interfere with blood-thinning treatments.
Buclizine hydrochloride: Buclizine may enhance the sedative effect of nervous depressants including alcohol, barbiturates, hypnotics, narcotics, analgesic, sedatives, and tranquilizers.
L-lysine hydrochloride: There are no known drug interactions.