Appetite Plus

Nutritional supplement to improve appetite & wt gain, & to support immune system function. Prevention & treatment of deficiencies in vit C & B-complex; vit A & D (cap only).

Cap Adult 1 cap bid, may be increased depending on patient's needs. Syr Childn >14 yr 15 mL daily, 7-14 yr 10 mL daily, 2-6 yr 5 mL daily.

Should be taken with food.

Hypersensitivity. Cap: Avoid use in patients w/ kidney stones, high Ca level in blood, or renal failure. Syr: Hyperoxaluria. Patients w/ renal failure given Al antacids.

Avoid use in patients w/ severe peptic ulcer. Buclizine: May cause drowsiness; exercise caution when engaging in activities eg, driving & use of machineries. Cap: Avoid use in patients w/ renal disease. Patients w/ G6PD deficiency, gallbladder disease, or diabetes. Syr: Vit C: Caution in patients w/ history of hyperoxaluria or those prone to develop oxalate kidney stones; patients w/ Fe overload requiring Fe chelation therapy (eg, thalassemia). High doses may induce hemolysis in patients w/ G6PD deficiency. Nicotinamide: Caution in patients w/ gallbladder disease or diabetes (when used in large doses); predisposed to gout. Consider use during pregnancy & lactation only if benefit outweighs risk.

Rarely, hypersensitivity reactions, constipation, vomiting, abdominal pain, yellow discoloration of urine, diarrhea, drowsiness, dryness of mouth, headache, & jitteriness. Cap: Rarely, numbness, irritability, loss of appetite, increased Ca in urine & blood. Syr: Vit C: Other GI disturbances & hyperoxaluria in high doses. May induce tolerance in prolonged intake of large doses resulting in deficiency symptoms upon resuming intake of normal doses. Vit B: Rarely, peripheral sensory neuropathy.

Cap: Patients taking contraceptive pills, neomycin, blood-thinning medications, laxatives, Ca supplements, thiazide diuretics, anticonvulsants, fluorouracil, levodopa, altretamine, aspirin, PPIs, H₂-receptor antagonists, colchicine, chloramphenicol, Fe supplements & chelating agents, Al antacids, oral citrate, analgesics, orlistat, bile acid sequestrants, alcohol, & CNS drugs. Syr: Vit B₁: Increased metabolism & blocked formation of thiamine pyrophosphate w/ fluorouracil which could further exacerbate preexisting thiamine deficiency in cancer patients. Vit B₆: Reduced effects of levodopa. High doses can decrease serum conc of phenytoin & phenobarb. Reduced effectiveness of altretamine (hexamethyl melamine). Vit B₁₂: Reduced gut absorption w/ aspirin, PPIs, H₂-receptor antagonists, neomycin, colchicine. May cause milder, reversible bone marrow depression w/ chloramphenicol. Vit C: Intestinal absorption may be reduced w/ aspirin. Bioavailability may be affected w/ PPIs. High doses may cause cardiac toxicity w/ deferoxamine in patients w/ Fe overload. May increase absorption of Fe in Fe-deficiency states & w/ other Fe chelating agents. May predispose patient to potentially fatal encephalopathy w/ Al antacids & oral citrate in patients w/ renal failure due to markedly increased blood Al levels. Prolonged presence of paracetamol in the blood. Interferes w/ blood-thinning treatments. Buclizine: May enhance sedative effect of nervous depressants including alcohol, barbiturates, hypnotics, narcotics, analgesic, sedatives, & tranquilizers.

Appetite Enhancers

R06AE51 - buclizine, combinations ; Belongs to the class of piperazine derivatives used as systemic antihistamines.

Cap: Non-Rx; Syr: Rx