Anpheclor Mechanism of Action

Pharmacology: Pharmacodynamics: Antimicrobial Action: Chloramphenicol (Anpheclor) is a broad-spectrum antibiotics which acts by interfering with bacterial protein synthesis. It is usually bacteriostatic and is effective against a wide range of Gram-negative and Gram-positive organisms including Salmonella typhi, Haemophilus influenzae, Neiserria meningitidis, Streptococcus pneumonia, and Bacteriodes fragilis.
Pharmacokinetics: Chloramphenicol (Anpheclor) is readily absorbed when given by mouth. Blood concentrations of about 10 μg per mL may be reached 2 hours after a single dose of 1 g by mouth; dose of 500 mg every 6 hours usually maintains blood concentrations above 4 μg per mL. Chloramphenicol palmitate (Anpheclor) is hydrolysed to Chloramphenicol (Anpheclor) in the gastro-intestinal tract prior to absorption, and the sodium succinate, which is given parenterally, is hydrolysed to free drug in the liver, and kidneys.
Chloramphenicol palmitate (Anpheclor) is widely distributed in body tissues and fluids, even in the absence of meningitis, giving concentrations of about 50% of those existing in the blood; it defuse across the placenta into the fetal circulation, into breast milk, and into the aqueous and vitreous humors of the eye.