Chloramphenicol (Anpheclor) may cause serious and sometimes fatal adverse effects such as depression of the bone marrow, aplastic anemia, hemolytic anemia, hypersensitivity reaction may occur especially after topical use. Gastro-intestinal symptoms including nausea, vomiting, and diarrhea can follow oral administration. Disturbances of the oral and intestinal flora may cause stomatitis, glossitis, and rectal irritation.