Xyloproct Special Precautions

Before prescription the patient should be investigated to exclude a malign process. Contact with eyes shall be avoided. The hands should be washed after usage.
Prolonged use of large doses of hydrocortisone can result in systemic effects or local effects such as skin atrophy. With recommended doses and treatment periods that do not exceed 3 weeks, systemic effects of hydrocortisone are unlikely.
In the event of infections caused by viruses, bacteria, pathogenic fungi or parasites, local glucocorticoids must not be used without concomitant causal therapy.
In the event of irritation or rectal bleeding the treatment should be discontinued and the patient investigated.
Local irritation can sometimes be due to hypersensitivity to lidocaine or hydrocortisone, and in such cases the treatment should be discontinued.
Overdosage of lidocaine or short intervals between the doses can result in high plasma levels of lidocaine and serious adverse events. The patients must be instructed to follow the recommended posology carefully.
Patients treated with class III antiarrhythmic drugs (e.g. amiodarone) should be closely observed and ECG monitoring should be considered, as the cardiac effects of lidocaine and class III antiarrhythmic drugs can be additive.
When applying Xyloproct rectal ointment to the rectum, care should be taken to avoid the introduction of an excessive amount.
With rectal administration the systemic availability is relatively high, and large doses can cause effects on the central nervous system.
Xyloproct rectal ointment contains cetyl alcohol and stearyl alcohol, which can cause local skin reactions (e.g. dermatitis).
The active substance lidocaine is probably porphyrinogenic and should only be prescribed to patients with acute porphyria when no safer alternative is available. Precautions are motivated in all patients with porphyria.
Effects on ability to drive and use machines: Depending on the amount of dose local anaesthetics may have a mild temporary effect on the ability to move and the coordination. With recommended doses of Xyloproct these effects are unlikely.