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The following combinations together with Xyloproct may need dose adjustment: Xyloproct should be used with caution together with dental injection anaesthesia, other local anaesthetics or agents structurally related to local anaesthetics of amide type, for example antiarrhytmic drugs such as mexiletine, as the toxic effects of these drugs are additive (see "Overdosage").
Patients treated with class III antiarrhythmic drugs (e.g. amiodarone) should be closely observed and ECG monitoring should be considered, as the cardiac effects of lidocaine and class III antiarrhythmic drugs can be additive.
Drugs that inhibits the metabolism of lidocaine (eg, cimetidine or betablockers) may cause potentially toxic plasma concentrations when lidocaine is given in repeated high doses over a long time period. Such interactions are of no clinical importance following short-term treatment with lidocaine at recommended doses.
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