Xyloproct Overdosage

Lidocaine can cause acute toxic effects after overdose. No toxic effects have been reported with use of recommended doses of Xyloproct.
If symptoms of systemic toxicity do occur, the signs are anticipated to be similar to those following the administration of local anaesthetics by other routes.
Concomitant use of other local anaesthetics, for example topically or by injection, the toxic effects are additive and can cause overdosage with toxic systemic reactions.
Overdosage of local anaesthetics causes symptoms in the form of effects on the central nervous system, and in severe cases also the heart and blood circulation.
Treatment: If signs of acute systemic toxicity occur the administration of local anaesthetics must be stopped immediately. Treatment must be given to maintain good ventilation, oxygenation and circulation. Oxygen must always be given, and assisted ventilation if necessary. If convulsions do not cease spontaneously within 15-20 seconds, thiopentone sodium 1-3 mg/kg should be given intravenously to facilitate ventilation or diazepam 0.1 mg/kg intravenously (acts rather more slowly). Prolonged seizures jeopardise the patient's respiration and oxygenation. Injection of muscle relaxants (e.g. suxamethonium 1 mg/kg) creates more favourable conditions for ventilation and oxygenation of the patient, but requires experience of tracheal intubation and controlled ventilation. In cases of a fall in blood pressure/bradycardia, a vasopressor should be given (e.g. ephedrine 5-10 mg intravenously, which may be repeated after 2-3 minutes).
In the event of circulatory arrest, cardiopulmonary resuscitation should be instituted immediately. It is important to maintain good oxygenation, respiration and circulation, and to treat acidosis.