Immune system disorders: In rare cases generalized rash or fever may occur. General disorders and administrative site conditions: Local site reactions such as bruising, pain, redness, swelling and itching. Oedema. Occasionally allergic reactions have been reported, mostly manifesting as pain and/or rash at the injection site. Tiredness.
Nervous system disorders: Headache.
Psychiatric disorders: Mood changes.
In the female: Reproductive system and breast disorders: Unwanted ovarian hyperstimulation, mild or severe ovarian hyperstimulation syndrome (OHSS): Mild OHSS: painful breasts, mild to moderate enlargement of ovaries, ovarian cysts, Abdominal pain, Abdominal discomfort, Gastrointestinal symptoms such as nausea, diarrhoea and bloating. Severe OHSS: Large ovarian cysts (prone to rupture), Acute abdominal pain, Ascites, Weight gain, Hydrothorax. In rare instances, thromboembolism has been associated with FSH/hCG therapy. Not all symptoms described are always associated to OHSS.
In the male: Metabolism and nutrition disorders: Water and sodium retention is occasionally seen after administration of high dosages; this is regarded as a result of excessive androgen production. Reproduction system and breast disorders: HCG treatment may sporadically cause gynaecomastia. Skin and subcutaneous tissue disorders: Acne may occur occasionally during hCG therapy.
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