HuCog: Dosing, Side Effect & Interaction

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Chorionic gonadotrophin

Indications/Uses

Female ovulation induction in subfertility due to anovulation or impaired follicle-ripening; preparation of follicles for puncture in controlled ovarian hyperstimulation programs (for medically assisted reproductive techniques); luteal phase support. Male hypogonadotropic hypogonadism, cases of idiopathic dysspermias; delayed puberty associated w/ insufficient gonadotropic pituitary function; cryptorchidism not due to anatomical obstruction.

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Dosage/Direction for Use

IM/SC Female Ovulation induction in subfertility due to anovulation or impaired follicle-ripening & preparation of follicles for puncture in controlled ovarian hyperstimulation programs 5,000-10,000 IU as single inj to complete treatment w/ FSH-containing prep. Luteal phase support 1,000-3,000 IU as 2-3 repeat inj given w/in 9 days following ovulation or embryo transfer. Male Hypogonadotropic hypogonadism 1000-2000 IU 2-3 times wkly. Delayed puberty associated w/ insufficient gonadotropic pituitary function 1,500 IU 2-3 times wkly for at least 6 mth. Cryptorchidism Childn >6 yr 1,500 IU twice wkly for 6 wk, <6 yr 500-1,000 IU twice wkly for 6 wk, <2 yr 250 IU twice wkly for 6 wk.

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Overdosage

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Contraindications

Hypersensitivity to human gonadotropins. Known or suspected sex hormone-dependent tumours eg, ovary, breast & uterine carcinoma in female & prostatic or breast carcinoma in male. Sexual organ malformations & uterine fibroid tumours incompatible w/ pregnancy.

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Special Precautions

Discontinue use if unwanted hyperstimulation occurs. Not to be used for body wt reduction. Asthma, epilepsy, migraine or cardiac disorders. Polycystic ovarian disease, ovarian enlargement or cysts, acute abdominal pain, superovulation or multiple pregnancies. Latent or overt cardiac failure, HTN. Risk factors for thrombosis eg, personal or family history, severe obesity (BMI >30 kg/m²) or thrombophilia. Perform ultrasonography to determine oestrogen levels & assess ovarian size prior to & at regular intervals during treatment. Regularly monitor skeletal maturation. Renal disorders. Not to be used during pregnancy & lactation. Prepubertal boys to avoid premature epiphyseal closure or precocious sexual development.

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Use In Pregnancy & Lactation

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Adverse Reactions

Local inj site reactions eg, bruising, pain, redness, swelling, itching; oedema; tiredness; headache; mood changes; unwanted ovarian hyperstimulation, mild or severe ovarian hyperstimulation syndrome; water & Na retention; gynaecomastia; acne.

Drug Interactions

Interference w/ serum/urinary hCG immunological determination leading to false +ve pregnancy test.

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Storage

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Description

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Action

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MIMS Class

Trophic Hormones & Related Synthetic Drugs

ATC Classification

G03GA01 - chorionic gonadotrophin ; Belongs to the class of gonadotropins. Used as ovulation stimulants.

Regulatory Classification

Presentation/Packing

Form

HuCog powd for inj 5,000 IU

Packing/Price

1's

HuCog

chorionic gonadotrophin

Manufacturer:

BSV Bioscience

Distributor:

Antah Pharma