HuCog Mechanism of Action

ATC Code: G03GA01-Chorionic Gonadotropin.
Pharmacology: Pharmacodynamics: HCG is a preparation of human chorionic gonadotrophin obtained from the urine of pregnant women. It stimulates the steroid genesis in the gonads by virtue of a biological effect similar to that of LH (Luteinizing hormone, which is the same as interstitial cell stimulating hormone). In the male it promotes the production of testosterone and in the female the production of estrogens and particularly of progesterone after ovulation. In certain cases, this preparation is used in combination with human menopausal gonadotrophin (HMG).
Pharmacokinetics: (HCG) is administered by intramuscular injection. The maximum serum level of (HCG) is reached after 4 to 12 hours (dose-dependent) and decreases afterwards with a half-life of 29 to 36 hours. Due to the slow elimination, (HCG) may cumulate in serum after several (e.g. daily) intramuscular injections. (HCG) is metabolized renally whereby about 10-20% can be found in its original form in urine, while the main amount is probably excreted as the beta-core fragment.