Captofen Special Precautions

Caution in patients with a history of drug allergy and bronchial asthma.
Patients with diseases of the gastrointestinal symptoms should be monitored, specifically the gastrointestinal bleeding. If bleeding or gastrointestinal peptic occur, treatment must be discontinued immediately.
As with other NSAIDs, it could potentially inhibit aggregation of platelets and prolong bleeding time through the inhibition of prostaglandins synthesis. Concomitant use of Dexketoprofen Trometamol with preventive dose of lower molecular weight of Heparin in postoperative shows that there is no effect for the coagulation parameter that already determined. However, the patients who have other therapy that affect hemostasis should be monitored carefully.
Increase of urea nitrogen and plasma creatinine can happen like other NSAIDs. As inhibitors of prostaglandin synthesis, side effects can occur in the renal system: glomerulonephritis, interstitial nephritis, renal papillary necrosis, nephrotic syndrome and acute renal failure.
As with other NSAIDs, these drugs can increase liver enzymes (temporary), if occur a significant increase in SGPT and SGOT, discontinue therapy immediately. Caution in patients with hematopoietic disorders, systemic lupus erythematosus, or a mixed connective tissue disease. The use of NSAIDs may mask the symptoms of the infection.
Caution in patients with impaired liver function, kidney or heart failure and other conditions that would cause fluid retention. In these patients, NSAID treatment can decrease kidney function and fluid retention. Caution in patients that already have diuretic therapy or hypovolemia incidence that can increase nephrotoxicity risk.
Use in Children: The safety of its use in children has not been established.
Use in the Elderly: Caution in elderly patients, are more susceptible to side effects: gastrointestinal bleeding and/or perforation, depending on the doses. While therapy, sometimes it can be more serious and occurring without warning or previous history. In elderly patients, the risk of kidney, cardiovascular and liver damage is increasing so their function should be monitored.