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Pharmacology: Dexketoprofen Trometamol is a tromethamine salt of S(+)-2-(3-benzoylphenyl) propionic acid, is an analgesic, anti-inflammatory and antipyretic belong to non-steroidal anti-inflammatory drugs (NSAIDs).
Mechanism of action of nonsteroidal anti-inflammatory drugs are associated with a reduction of prostaglandin synthesis by inhibition of cyclooxygenase pathway. Inhibition of the transformation of arachidonic acid into cyclic endeperoxide, PGG2 and PGH2, which produce prostaglandins; PGE1, PGE2, PGF2a and PGD2 and also prostacyclin PGl2 and thromboxane (TxA2 and TxB2) specifically occur. Furthermore, inhibition of prostaglandin synthesis can affect other inflammatory mediators such as kinin, causing indirect action that strengthens direct action.
