Captofen

Dexketoprofen trometamol

Symptomatic treatment of acute pain intensity where PO is inadequate eg, post-op pain.

IV/IM inj 50 mg every 8-12 hr, may be repeated every 6 hr. Max daily dose: 150 mg. Mild kidney & mild to moderate hepatic impairment Total daily dose: 50 mg.

Hypersensitivity to dexketoprofen or other NSAIDs. Patients w/ asthma attack, bronchospasm, acute rhinitis, nasal polyps, urticaria or angioneurotic edema triggered by similar substances eg, aspirin or other NSAIDs; history of active or new suspicion gastric ulcer, chronic dyspepsia, gastric or other active bleeding, Crohn's disease or ulcerative colitis, bronchial asthma, severe heart failure, haemorrhagic diathesis & other coagulation disorders. Peri-op pain in CABG surgery. Neuraxial (intrathecal or epidural) administration. Patients treated w/ anticoagulants. Severe hepatic dysfunction (Child-Pugh score 10-15). Moderate to severe renal dysfunction (CrCl <50 mL/min). Pregnancy & lactation.

History of allergy & bronchial asthma. Discontinue treatment if GI bleeding or peptic ulcer, significant increased SGPT & SGOT occurs. Increased risk of serious CV thrombosis, MI & stroke in patients w/ CV disease or risk factors for CV disease. Hematopoietic disorders, SLE or mixed connective tissue disease as use may mask symptoms of infectious diseases. Heart failure & other conditions causing fluid retention; hypovolemia. Increased urea nitrogen & plasma creatinine. Long-term use. Monitor patients treated w/ other therapy affecting hemostasis. Patients treated w/ diuretics. Hepatic & renal dysfunction. Not to be given in childn. Elderly.

Nausea, vomiting, pain at administration site, anemia, headache, dizziness, insomnia, drowsiness, blurred vision, hypotension, hot flushes, abdominal pain, dyspepsia, diarrhea, constipation, vomiting blood, dry mouth, dermatitis, pruritus, skin rashes, excessive sweating, reaction in inj area, inflammatory bruise or bleeding, fever, fatigue, pain, coldness, hyper- & hypoglycemia, hypertriglyceridemia, paresthesia, tinnitus, extrasystole, tachycardia, HTN, peripheral edema, superficial thrombophlebitis, bradypnea, peptic ulcers, bleeding or gastroduodenal perforation, anorexia, elevated liver enzyme, liver disorders, jaundice, urticaria, acne, stiff joints, muscular cramp, polyuria, kidney & back pain, menstrual & prostatic disorders, syncope, chills, ketonuria, proteinuria, neutropenia, thrombocytopenia, bronchospasm, dyspnea, pancreatic & liver damage, severe mucocutaneous skin reaction (SJS, Lyell's syndrome), angioedema, dermatology & photosensitivity reaction, pruritus, kidney damage (nephritis or nephrotic syndrome), anaphylaxis, face edema.

Ulcers & GI bleeding w/ other NSAIDs. Increased risk of bleeding w/ pentoxifylline & thrombolytic drugs & damaged GI mucosa w/ anticoagulants, heparin prophylaxis, ticlopidine. Increased blood levels of lithium. Increased toxicity of MTX; hydantoins & sulfonamides. Increased risk of RBC poisoning w/ zidovudine. Reduced anti-hypertensive effects of diuretics & β-blockers. Increased hypoglycaemic effect of sulfonylureas. Increased nephrotoxicity w/ cyclosporine & tacrolimus. Increased blood levels w/ probenecid. Increased blood levels of glycosides. Changed efficacy of mifepristone. Increased risk of convulsions w/ high-dose quinolones.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

M01AE17 - dexketoprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.

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