Captofen Drug Interactions

Ulcers and gastrointestinal bleeding may occur in the concomitant use with other NSAIDs, for their synergistic effect.
There may be an increased risk of bleeding and damage to the gastrointestinal mucosa on the concomitant use with anticoagulant drugs, above Heparin prophylaxis dose parenterally, as well as Ticlopidine.
NSAIDs can increase lithium level in the blood until toxic levels, so it needs to be monitored.
On the use of Methotrexate above 15 mg/week or more, NSAIDs may increase Methotrexate toxicity in blood because of clearance through the kidney decreased.
There may be an increase in the toxicity of hydantoins and sulfonamides, if used concomitantly with NSAIDs.
Reduction of antihypertensive effects of diuretics and [3-blockers group (keep out there is no dehydration).
There is an increased risk of bleeding in concomitant use with Pentoxifylline and thrombolytic drugs.
An increase poisoning of red blood cells (reticulocytes influence) on the concomitant use with Zidovudine.
An increase in hypoglycaemic effect of sulfonylurea class of drugs.An increase of nephrotoxicity in the use of Cyclosporine and Tacrolimus by NSAIDs. During combination therapy, renal function should be monitored.
An increase in hypoglycaemic effect of sulfonylurea class of drugs.
An increase of nephrotoxicity in the use of Cyclosporine and Tacrolimus by NSAIDs. During combination therapy, renal function should be monitored.
An increase in the blood levels of Dexketoprofen on concomitant use with Probenecid.
Cardiac glycosides: NSAIDs may increase blood levels of glycosides.
Mifepristone: NSAIDs should not be used within 8-12 days after Mifepristone use. Because theoretically an inhibitor of prostaglandin synthesis can change the efficacy of Mifepristone.
Quinolone antibiotics: high doses of quinolone and NSAIDs may increase the risk of convulsions.