Like all medicines, this medicine can cause side effects, although not everybody gets them.
The most common adverse reactions with this medicine are dose dependent and related to its mode of action: Very common (may affect more than 1 in 10 people): Luminous visual phenomena (brief moments of increased brightness, most often caused by sudden changes in light intensity). They can also be described as a halo, coloured flashes, image decomposition or multiple images. They generally occur within the first two months of treatment after which they may occur repeatedly and resolve during or after treatment.
Common (may affect up to 1 in 10 people): Modification in the heart functioning (the symptoms are a slowing down of the heart rate). They particularly occur within the first 2 to 3 months of treatment initiation.
Other side effects have also been reported: Common (may affect up to 1 in 10 people): Irregular rapid contraction of the heart (Atrial fibrillation), abnormal perception of heartbeat (Bradycardia, Ventricular extrasystoles, AV 1st degree block (ECG prolonged PQ interval)), uncontrolled blood pressure, headache, dizziness and blurred vision (cloudy vision).
Uncommon (may affect up to 1 in 100 people): Palpitations and cardiac extra beats, feeling sick (nausea), constipation, diarrhoea, abdominal pain, spinning sensation (vertigo), difficulty breathing (dyspnoea), muscle spasms, high blood levels of uric acid, an excess of eosinophils (a type of white blood cell) and elevated creatinine in blood (a breakdown product of muscle), skin rash, angioedema (such as swollen face, tongue or throat, difficulty in breathing or swallowing), low blood pressure, fainting, feeling of tiredness, feeling of weakness, abnormal ECG heart tracing, double vision, impaired vision.
Rare (may affect up to 1 in 1,000 people): Urticaria, itching, skin reddening, feeling unwell.
Very rare (may affect up to 1 in 10,000 people): Irregular heartbeats (AV 2nd degree block, AV 3rd degree block, Sick sinus syndrome).
Reporting of side effects: If the patient gets any side effects, the patient must be advised to talk to the doctor or pharmacist. This includes any possible side effects not listed in this monograph. Reporting side effects can help provide more information on the safety of this medicine.
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