Zanidip Dosage/Direction for Use

The recommended dose is 10 mg orally, once a day before meals; the dose may be increased to 20 mg depending on the individual patient's response. Dose titration should be gradual because it may take about 2 weeks before the maximal antihypertensive effect is apparent. In severe hypertension, the dose titration period should be reduced.
Children: Since there is no clinical experience in patients under age of 18 years, use in children is not currently recommended.
Elderly: Although the pharmacokinetic data and clinical experience suggest that no adjustment of the daily dosage is required, special care should be exercised when initiating treatment in the elderly.
Renal or Hepatic Dysfunction: Special care should be exercised when treatment is recommenced in patients with renal or hepatic dysfunction. Although the usually recommended dose schedule may be tolerated by these subgroups, an increase in dose to 20 mg daily must be approached with caution. ZANIDIP is not recommended for use in patients with severe hepatic or renal dysfunction.