Zanidip Adverse Reactions

Treatment with ZANIDIP is generally well tolerated. In controlled clinical trials the most commonly observed side effects were related to the vasodilatory properties of lercanidipine: Flushing, peripheral oedema, tachycardia, palpitation, headache, dizziness, asthenia. Other adverse experiences which were not clearly drug related and which occurred in less than 1% of patients were: Fatigue, gastrointestinal disturbances such as dyspepsia, nausea, vomiting, epigastric pain and diarrhea, polyuria, rash, somnolence and myalgia.
Hypotension may occur in rare cases. Although not observed in clinical trials, gingival hyperplasia may rarely occur as reported following the use of other dihydropyridines. There were reports of isolated and reversible increases in serum levels of hepatic transaminases; no other clinically significant pattern of laboratory test abnormalities related to ZANIDIP has been observed. ZANIDIP dose not appear to influence adversely blood sugar or serum lipid levels. Some dihydropyridines may rarely lead to precordial pain or angina pectoris. Very rarely patients with pre-existing angina pectoris may experience increased frequency, duration or severity of these attacks. Isolated cases of myocardial infarction may be observed.