One case of tamsulosin overdose (30 capsules of 0.4 mg) was reported with severe headache. Due to highly protein binding, tamsulosin is not readily dialyzable. Thus, symptomatic and supportive treatment should be administered as appropriate. There is no specific antidote for tamsulosin overdose. Restore blood pressure and normalize heart rate by keeping the patient supine. Treat shock with volume expanders or vasopressors, if necessary.