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Concomitant Use with Potent CYP Inhibitors/Inducers: Tamsulosin is metabolized by CYP3A4 and 2D6 enzyme systems. Thus, tamsulosin may have interactions with other medications which have high capability in inhibition or induction of such enzyme systems. Concomitant use of tamsulosin with potent CYP inhibitors such as cimetidine, clarithromycin, itraconazole, ketoconazole, verapamil and ritonavir may increase plasma levels of tamsulosin and potentiate cardiovascular toxicities of tamsulosin. Therefore, concomitant use with potent CYP inhibitors should be avoided.
Concomitant Use with Other Antihypertensive Agents: There was an increased incidence as well as severity of orthostatic hypotension when tamsulosin and other antihypertensive agents were administered together, other alpha-adrenergic blockers and beta-adrenergic blockers. Special precaution with routinely monitoring should be exercised.
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