Uroflow Dosage/Direction for Use

General recommendation: The usual initial dose for adult patients is 0.4 mg once daily. Dosage may be increased to 0.8 mg daily as needed to achieve the desired improvement in clinical symptoms and/or urinary flow rates. Approximately 2-4 weeks may be necessary to assess the response before recommendation of subsequent dosage adjustment.
Dosage Adjustment in Renal Impairment: Protein binding of tamsulosin may be altered in patients with impaired renal function either mild to moderate (creatinine clearance of 30-70 mL/min per 1.73m²) or severe (creatinine clearance of 10 to less than 30 ml/min per 1.73 m²). However such changes are not warranted for dosage adjustment. Tamsulosin has not been studied in end-stage renal patients (creatinine clearance of less than 10 mL/min per 1.73 m²).
Dosage Adjustment in Hepatic Impairment: Although protein binding property, plasma concentrations and intrinsic clearance of tamsulosin may be altered in patients with impaired hepatic function. Dosage adjustment of tamsulosin is not necessary.
Administration: Uroflow is administered orally.
Although food may delay absorption, decreased bioavailability and decreased peak plasma concentration of tamsulosin, it is recommended that Uroflow can be taken with or without food. Uroflow should be swallowed whole, do not crush or chew the tablet.