Thromboflux Dosage/Direction for Use

An intradermal skin test of 100 I.U has been suggested to predict allergic response to Thromboflux. If positive reaction is not seen after 15 to 20 minutes, the therapeutic dose can be administered.
Thromboflux is administered by intravenous, intra-arterial, or intracoronary infusion.
Acute evolving transmural mtocardial infarction: Intravenous infusion: 1,500,000 I.U. Thromboflux is made up in 100 mL of physiological saline or Dextrose solution and administered over 30 to 60 minutes.
Alternatively intracoronary bolus doses of 10,000 to 30,000 I.U. have been administered in up to 20 mL infusion solution over 15 seconds to 2 minutes. Maintenance doses of 2000 to 4000 I.U./min for 60 minutes by intracoronary infusion have been given.
Deep vein thrombosis, pulmonary embolism, arterial thrombosis or embolism: A loading dose of 250,000 I.U. of Thromboflux in 100 to 300 mL of physiological saline or Dextrose solution infused into a peripheral vein over 30 minutes has been found appropriate as a standard dose. Following the loading dose, a maintenance infusion of Thromboflux 100,000 I.U./hour is given for 24 to 72 hours.
Occlusion of arterio-venous cannulae: Thromboflux equivalent to 250,000 I.U. may be administered over 25 to 35 mins. in 2 mL of solution to clear an occluded arterio-venous cannula. The drug is infused directly into the cannula which is then clamped for 2 hours, aspirated and flushed with physiological saline.
Local application in occluded haemodialysis shunts: 100 mL physiological saline containing Thromboflux 100,000 I.U.:10,000 to 25,000 I.U. (10 to 25 mL) is deposited in the clotted portion of shunt. Which is then sealed on the venous side with forceps. A sterile single dose syringe is attached on the arterial side to form an air cushion against which the artery can pulsate. If required, the treatment may be repeated after 30 to 45 minutes.