Peyona Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Caffeine citrate (equiv to 10 mg caffeine)

Indications/Uses

Primary apnoea of premature newborns.

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Dosage/Direction for Use

Previously untreated infants Loading dose: 20 mg/kg via slow IV infusion over 30 min. Maintenance dose: 5 mg/kg via slow IV infusion over 10 min every 24 hr (beginning 24 hr after loading dose); may also be administered via oral route eg, nasogastric tube every 24 hr. Preterm newborn infants w/ insufficient clinical response to recommended loading dose Second loading dose: 10-20 mg/kg max after 24 hr, then 10 mg/kg/day maintenance dose.

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Overdosage

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Contraindications

Hypersensitivity.

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Special Precautions

Do not administer by IM, SC, intrathecal or IP inj. Discontinue if patient has 5-7 days w/o significant apnoeic attack. Apnoea. Measure baseline plasma caffeine conc prior to initiation of treatment in newborn infants whose mother consumed large quantities of caffeine prior to delivery, & in newborns previously treated w/ theophylline. Extreme caution in newborns w/ seizure disorders. Known CV disease; unusual rhythm disturbances on a cardiotocograph (CTG) trace before delivery. GERD. Development of necrotising enterocolitis. Diuresis & electrolyte loss. Higher energy & nutrition requirements. Renal & hepatic impairment in preterm newborn infants. Pregnancy. Breastfeeding women should not ingest caffeine-containing foods & beverages, or drugs containing caffeine. Very premature infants (<28 wk gestational age &/or body wt <1,000 g).

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Use In Pregnancy & Lactation

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Adverse Reactions

Hyperglycaemia; tachycardia; infusion site phlebitis & inflammation; necrotising enterocolitis.

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Drug Interactions

Interconversion w/ theophylline. Decreased elimination in adults w/ cimetidine & ketoconazole. Increased elimination w/ phenobarb, phenytoin. May increase risk of necrotising enterocolitis w/ drugs that suppress gastric acid secretion eg, H₂ receptor blockers or PPIs. May potentiate cardioresp & CNS stimulatory effects w/ doxapram.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Peyona detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Other Drugs Acting on the Respiratory System

ATC Classification

N06BC01 - caffeine ; Belongs to the class of xanthine derivative agents. Used as CNS stimulant.

Thai FDA Category

Presentation/Packing

Form

Peyona soln for infusion 20 mg/mL

Packing/Price

10's

Peyona

caffeine

Manufacturer:

Chiesi Farmaceutici

Distributor:

Pacific Healthcare

Marketer:

Pacific Healthcare