Peyona Use In Pregnancy & Lactation

Pregnancy: Caffeine in animal studies, at high doses, was shown to be embryotoxic and teratogenic. These effects are not relevant with regard to short term administration in the preterm infant population (see Pharmacology: Toxicology: Preclinical safety data under Actions).
Breast-feeding: Caffeine is excreted into breast milk and readily crosses the placenta into the foetal circulation (see Pharmacology: Pharmacokinetics under Actions).
Breast-feeding mothers of newborn infants treated with caffeine citrate should not ingest caffeine-containing foods, beverages or medicinal products containing caffeine.
In newborn infants born to mothers who consumed large quantities of caffeine prior to delivery, baseline plasma caffeine concentrations should be measured prior to initiation of treatment with caffeine citrate (see Precautions).
Fertility: Effects on reproductive performance observed in animals are not relevant to its indication in the preterm newborn infants (see Pharmacology: Toxicology: Preclinical safety data under Actions).